Hair Loss Prevention May Reside In Stem Cell Research

Hair loss prevention seems to be entering a new phase in development. For those who suffer from thinning hair due to pattern baldness, there is now a new glimmer of hope that someday soon by simply administering a specially engineered medication, the stem cell part of your hair follicles will spring back to life. With the current stem cell research that has been underway for the last six years at Rockefeller University, it seems that exciting possibilities are emerging for the treatment of male and female pattern baldness.

As you age the resting phase of the hair cycle gets longer and longer and for those predisposed genetically for pattern baldness, the hair follicles go into a more permanent phase of dormancy. It was believed by scientists working for the project, that stem cells in hair follicles did not divide frequently so they could maintain their potency. This reduction in stem cell division was a protective measure from wear and tear. However, new data from recent research indicate that stem cells may not need as much protection as once assumed now that scientist have discovered the protein responsible for slowing down stem cell division.

Those working on the research project discovered that the protein NFATc1 acts to put the brakes on stem cell division and that when a drug called cyclosporine was administered in mice, the stem cells increased their processes that cranked up the production of hair. The hair cycle actually shifted from its resting phase, to its growth phase, when stem cells proliferate.

To maintain their multi potent properties, it appeared that the stem cells during this research project hardly needed much rest. It seems from the data gathered so far that the stem cells maintained their character without degradation, which should be good news for the future of hair loss prevention.

Using genetically engineered mice these researchers found that when blocking NFATc1 production, hair radically increased and NFATc1 didn't stop the hair cycle, but rather shortened the resting phase and prompted advanced entry to the growth state.

Researchers believe that it is possible to develop a local and more specific inhibitor of NFATc1 than the drug cyclosporine A to stimulate these stem cells to promote new hair growth without the side effects of dangerous tumor formation. The test they have run so far on mice showed no signs of tumorigenesis, which is often a dangerous byproduct of triggering stem cells into action.

Elaine Fuchs, head of the Laboratory of Mammalian Cell Biology made the following comments about their findings from their stem cell research. "This is the first case where we have been able to activate the hair cycle without the accompanying signs of tumorigenesis". "If we can control the activation process of follicle stem cells without promoting tumorigenesis, then this would be a big move in the right direction."

Though breakthroughs in the research laboratories offer great promise, it may take a decade or two before safe effective products will enter the market and have an impact on hair loss prevention. It's possible that the current research will relegate male and female pattern baldness as a thing of the past.

Article Source: http://www.healthandwellnesscentral.com

Untitled Nicky Taylor CEO of www.solid-hair-loss-resource.com/hairlossprevention.html Many interesting topics pertaining to hair loss prevention are covered at my website. Visit may site and become informed on how you can make a difference with your hair.

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